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Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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The ocean is home to all manner of mysteries, from “alien” shape-shifters to ancient shipwrecks. And so, when Richard Branson and a team of scientists took a submersible down to the bottom of Belize’s iconic Giant Blue Hole, they were braced for some truly extraordinary sights. The Blue Hole is the largest sinkhole in the world, measuring 300m (984 feet) across and around 125m (410 feet) deep but, until Branson’s expedition in 2018 its depths had not been fully explored. The British billionaire was joined on his groundbreaking journey by Fabien Cousteau – the grandson of pioneering underwater explorer Jacques Cousteau – and oceanographer Erika Bergman. Sign up for our free Indy100 weekly newsletter Their mission was to create a 3D map of the hole’s interior but, when they reached the bottom, they were met by some disturbing discoveries. To be fair, they got off to a good start. The first thing they encountered as they edged down the hole was a wall of giant stalactites, which were “breathtakingly beautiful,” according to Branson. Then, at around 300 feet, they pierced a thick layer of toxic hydrogen sulphide, plunging them into darkness and cutting out the oxygen from the water around them. In an interview with CNN, Bergman explained that once you pierce that layer, which forms naturally over centuries, “you lose all of that Caribbean sunlight and it just turns completely black.” Elsewhere, Branson described it as “extremely eerie,” saying: “We didn’t expect to see any creatures below. But when we got to the bottom we could see crabs, conches and other creatures that had fallen into the hole, arrived on the bottom and then ran out of oxygen and died.” As the team continued to travel further down into the abyss, they were faced with the remains of a tragedy. In an interview with Business Insider back in July 2020, Bergman revealed that they found the bodies of two people who have “been lost in the Blue Hole”. “We found the resting place of a couple [of] folks,” she said. “And we just sort of very respectfully let the Belize government know where we found them.” She added that “everyone decided that we would just not attempt any recovery”, noting: “It's very dark and peaceful down there, [so we] just kind of let them stay.” As they reached the bottom, the team found something else unexpected, and very much unwelcome: human rubbish. It came in the form of a 2-litre Coke bottle and a lost GoPro containing some holiday snaps, according to Business Insider. “As for the mythical monsters of the deep? Well, the real monsters facing the ocean are climate change – and plastic,” Branson lamented following the discovery. “Sadly, we saw plastic bottles at the bottom of the hole, which is a real scourge of the ocean.” The business magnate said the expedition had offered “one of the starkest reminders of the danger of climate change [he had] ever seen.” He pointed out: “The Blue Hole is made of a complex system of caves that once formed on dry land. It is proof of how oceans can rise quickly and catastrophically. “Sea levels were once hundreds of feet lower. 10,000 years ago the sea level rose by about 300 feet when a lot of ice melted around the world. At 300 feet down you could see the change in the rock where it used to be land and turned into sea.” He added in his blog: “Hopefully by this trip taking place we have raised even more awareness of the need to protect the ocean and tackle climate change now – before it is too late.” He stressed that he didn’t want his grandchildren to “grow up in a world without corals, without the wonders of the ocean”. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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