MUNICH--(BUSINESS WIRE)--Aug 28, 2023--

Here's the Fortnite OG Season 7 countdown to see how much longer until the next Fortnite OG update drops on Nov. 16, 2023, at 9 a.m. ET.

After two years co-piloting the biggest acquisition in video game history past an onslaught of challenges, Xbox CEO Phil Spencer now moves on to his next quest: making Microsoft’s takeover of Activision Blizzard worth the hassle

Veteran tech journalist Walt Mossberg announced on Tuesday he was deactivating his X (formerly known as Twitter) account, saying Elon Musk’s takeover of the site turned it into a “cesspool.” Mr Mossberg is a well-respected name and expert in the US tech writing industry, who also co-founded media sites such as Recode and AllThingsD. He announced his boycotting of X on Meta’s new platform Threads, saying his reasons revolve around business tycoon Mr Musk’s threats to sue the Anti-Defemation League (ADL). Mr Musk is threatening to sue the ADL for around $22bn, claiming that the Jewish civil rights group is “destroying” his platform’s value by accusing him of antisemitism. Mr Mossberg cut back his usage of X after Mr Musk bought back controversial figures accounts when he took over ownership of Twitter. Among others, Mr Musk restored the accounts of media personality Andrew Tate, who has been charged over rape and human trafficking claims, as well as Rep Majorie Taylor Greene, who is known for spreading conspiracy theories. “Under Elon Musk, Twitter has not only decided to stop blocking bigots and liars and pro- insurrectionists, it has actively welcomed them, with apparent support from Mr. Musk. I had already cut my participation there by 90%. But Musk’s latest move, to threaten to ban and sue the ADL – to the delight of antisemites and other haters – is the last straw for me,” Mr Mossberg wrote on Threads. He continued on to say he will only be found on Threads, Facebook, LinkedIn and Instagram. “They have their own drawbacks. (I even boycotted Meta for awhile pre-pandemic over privacy issues). But none comes close to the cesspool of Twitter under Musk, which, IMO, is steadily approaching the level of Truth Social,” he wrote. Mr Mossberg famously quit Facebook back in 2018 “because my own values and the policies and actions of Facebook have diverged to the point where I’m no longer comfortable here”. This time, Mr Mossberg has quit X over fears that “antisemites and other haters” will revel in Mr Musk’s decision to ban and sue the ADL. “It is profoundly disturbing that Elon Musk spent the weekend engaging with a highly toxic, anti-Semitic campaign on his platform,” ADL CEO Johnathan Greenblatt said in a statement. “But to be clear, the real issue is neither ADL nor the threat of a frivolous lawsuit. This urgent matter is the safety of the Jewish people in the face of increasing, intensifying antisemitism.” While there has yet to be a lawsuit filed, Mr Musk took to X to promote the hashtag #BantheADL, which inevitably became popular amongst the far-right X community. Before retiring from journalism back in 2017, Mr Mossberg wrote for The Wall Street Journal for over twenty years. His admired status makes his leave from X ten times louder in the media industry. Read More Elon Musk vows to sue ADL for calling him antisemitic after he promoted antisemitic campaign on X Why is Elon Musk obsessed with the letter X? Elon Musk calls Burning Man ‘best art on Earth’ amid chaos that saw thousands stranded and one dead SpaceX launch of Starship rocket on hold amid ‘mishap investigation’ Why is Elon Musk obsessed with the letter X? Elon Musk ‘borrowed $1bn from SpaceX’ at same time as Twitter acquisition

SAN FRANCISCO--(BUSINESS WIRE)--Aug 4, 2023--

By Jeffrey Dastin SAN FRANCISCO Amazon.com on Monday said it will invest up to $4 billion in cash

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

One of the benefits of Spotify Premium is that users can download their favorite songs,

MW3 Season 1 likely starts on Wednesday, Dec. 6, 2023, and includes the MW3 Battle Pass, Urzikstan, and new multiplayer maps.

BENTONVILLE, Arkansas Walmart on Wednesday said it has not made any changes to its merchandise tied to Pride

CHELMSFORD, England--(BUSINESS WIRE)--Jun 6, 2023--

Peloton is undergoing a significant rebrand, dumping its identity as a seller only of luxury exercise bikes to a heath app for all