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By Renee Maltezou and Angeliki Koutantou ATHENS (Reuters) -Thousands of tourists and residents fleeing a wildfire on Rhodes huddled in

A natural phenomenon consisting of polka-dot-style formations has been cropping up around the world, and scientists are baffled as to why. The circular-shaped patches of ground have been seen in deserts in Australia and Namibia but now experts believe they are more widespread than originally thought. Known as “fairy circles”, there are now 263 known sites across the globe where they can be found, according to new research published in the journal Proceedings of the National Academy of Sciences (PNAS). They have been documented in 15 countries, across three continents, including the Sahel region of Africa, Madagascar, and in Middle-West Asia. And yet, despite the spread of these anomalies, scientists are still none the wiser about how they actually form. A team led by environmental scientist Emilio Guirado, of the University of Alicante in Spain, explained in their paper on the "intriguing" phenomenon: “We conducted a global and systematic assessment of fairy circle-like vegetation patterns and discovered hundreds of [fairy-circle]-like locations on three continents. “Our study provides insights into the ecology and biogeography of these fascinating vegetation patterns and the first atlas of their global distribution.” The mysterious circles appear in desert regions and can be as wide as 12 metres (39 feet) in diameter. They are almost always spaced out and rarely connect or overlap with one another. Several theories have been put forward as to what causes them, including, tiny insects, termites, and plant toxins. But, none have been accompanied by any significant evidence and some have been debunked completely. One significant factor limiting their study is they are often found in places that are difficult to access and are inhospitable. Locating the 263 different sites of “fairy circles” involved analysing high-resolution satellite imagery. Guirado and his team wrote in their paper: “[The sites] include those already identified in Namibia and Western Australia, as well as areas never described before, including the Sahel, Western Sahara, Horn of Africa, Madagascar, Southwest Asia, or Central and Southwest Australia. “By doing so, our study provides a global atlas of areas showing FC-like vegetation patterns and expands the known existence of this vegetation type to new countries and continents.” The team hopes that locating new sites will enable them to find common traits that may point towards their cause. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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