Shares of chip designer Arm Holdings are trading just ahead of the IPO price. A flock of Wall Street analysts are backing the stock to rise from here.

LAKE MARY, Fla.--(BUSINESS WIRE)--May 16, 2023--

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Stablecoin issuer Tether has added Britannia Bank & Trust, a privately-held bank operating in the Bahamas, to process

A fake image purporting to show an explosion near the Pentagon was shared by multiple verified Twitter accounts on Monday, causing confusion and leading to a brief dip in the stock market. Local officials later confirmed no such incident had occurred.

CHICAGO--(BUSINESS WIRE)--Jun 23, 2023--

LAS VEGAS--(BUSINESS WIRE)--Sep 19, 2023--

You only get two eyes in this lifetime, so it’s important to keep ‘em as healthy and stylish as possible. On those supremely bright and sunny days, that means putting on a pair of trendy sunglasses to protect your delicate pupils from harmful UV rays — or from paparazzi flashes, or from things falling from the sky (which, who knows, could all totally happen).

Here's some inspiration for Xbox controller designs!

Nasa’s chief says he believes that aliens are real and waiting to be found. Bill Nelson was speaking after the publication of a report by a panel assembled to look into Unidentified Anomalous Phenomena (UAPs), the official names for UFOs, or unexplained objects spotted in the sky. That report found that while some UAPs remain unexplained, more data is found to understand where they have come from. Mr Nelson said that his “personal answer” is that there are vast numbers of inhabited planets throughout the universe. “With the James Webb [telescope] looking at the exoplanets, we are now beginning to discover, and somewhere out there we will discover, another medium-sized stony planet around a medium-sized sun or star at just the right distance... that has carbon, that will have a habitable atmosphere,” he said. “If you ask me do I believe there’s life in a universe that is so vast that it’s hard for me to comprehend how big it is, my personal answer is yes. But I asked some of our scientists: What is the mathematical probability that there is life out there in the universe? And if you calculate in billions of stars in billions of galaxies that there’s replicated in what I just said, another stony planet, the answer was ‘at least a trillion’. That’s from our scientists.” Read More Watch live: Nasa announces findings of long-awaited UFO study We cannot yet explain mysterious sightings in the sky, Nasa panel says Nasa’s UFO study team reveals first ever report: Live updates

REDMOND, Wash.--(BUSINESS WIRE)--Aug 31, 2023--

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.