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Become the master of stealth

Being two-faced doesn’t have a positive connotation, but let’s set that aside for the duration

BOSTON--(BUSINESS WIRE)--Jun 21, 2023--

This California summer, passersby on the streets of San Francisco can be divided into two camps: blase locals who are used to a parade of moving cars with no drivers or gobsmacked tourists fumbling for their smartphones to...

Scientists have grown human kidneys in pigs, for the very first time. Researchers at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and Wuyi University created human-pig chimeric embryos containing a combination of human and pig cells. When they transferred into 13 surrogate pig mothers, they developed kidneys that contained mostly human cells at a rate of 50 to 60 per cent, giving hope for potential transplants in the future. “Rat organs have been produced in mice, and mouse organs have been produced in rats, but previous attempts to grow human organs in pigs have not succeeded,” said the senior author Liangxue Lai. “Our approach improves the integration of human cells into recipient tissues and allows us to grow human organs in pigs.” The kidneys were not entirely human as they included vasculature and nerves made mostly from pig cells, meaning they could not be used for transplantation in their current form, but it is still a pretty impressive step. And apart from the kidneys, the embryos were dominated by pig cells, with very few human cells in the brain or central nervous system. Making brains using human and pig cells is very controversial for ethical reasons, so there are tight regulations for this kind of research. Meanwhile, pig cells tend to outcompete human cells during development, so previous experiments have created embryos that are almost entirely pig. The latest work, published in Cell Stem Cell, overcame this by genetically engineering a single-cell pig embryo so that it lacked two genes needed for kidney development. This created a gap within the embryo that could be filled by human cells. “We found that if you create a niche in the pig embryo, then the human cells naturally go into these spaces,” said Prof Zhen Dai of Guangzhou Institutes of Biomedicine and Health, another senior author. The scientists said that being able to incubate a fully human kidney inside a pig would be likely to take many years. “We would probably need to engineer the pigs in a much more complex way and that also brings some additional challenges,” said Miguel Esteban, also of the Guangzhou institute and a senior author. A central challenge would be to allow human nerves and vasculature to develop within the target organ without nerve cells developing in the central nervous system that could lead to a humanised brain. “Even theoretically it’s not clear how you’d do that,” said Ilic. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Golf influencer Paige Spiranac has hit out at “‘hypocrites” who enjoyed a performance of “semi-naked” men before a baseball game. Spiranac has often spoken about the negative attitudes she faces as a former professional golfer and influencer posting supposedly ‘risque’ content on Instagram. The 30-year-old shared her own experiences in a new Twitter post, claiming that people online were hypocritical for cheering a performance of men dancing topless while at the same time “harshly treating” her content. Spiranac posted a video of the dancing duo named “the Savannah Party Animals” who appeared before a recent baseball game wearing only trousers and cowboy hats. Sign up to our free Indy100 weekly newsletter Giving her take, she wrote: "Interesting how different the reaction is online when men choose to show off their bodies. “Not one comment on this video calling them attention w****s or s***s. Just a ton of women saying baseball is now their favourite sport but those same women harshly judge me. The hypocrisy lol." Spiranac has spoken about being judged by members of the golfing world in the past, including when she offered a set of clubs to a charity auction – only to be rejected because of her “cleavage”. Speaking on her podcast Playing-A-Round with Paige, she said: “I wanted to help this charity out and I wanted to give them free golf clubs. "The guy wrote back and said, ‘We would love to but, because of the way our board members view you, you can’t help out’. I want to give back to these kids who don’t have anything, because I grew up not having anything. And I can’t even f***ing do that because of my cleavage.” Spiranac also recently clapped back at a TikTok troll who accused her of "insulting men" with her outfit choice. The golf influencer was wearing a grey bodysuit as she demonstrated to her 1.4m followers how to hit a certain type of golf shot by changing their set up in a video earlier this year. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

The Big Tech rally looks to be diversifying. European stocks could provide a way to play a broader technology cycle at cheaper prices.

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Travis Barker's daughter Alabama's ex-boyfriend DD Osama, commented on her photo giving rise to more rumors among fans

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An overview of the media in Bahrain, including links to broadcasters and newspapers.