A married couple from New York dubbed "Bitcoin Bonnie and Crypto Clyde" pleaded guilty on Thursday to laundering billions of dollars...

SpaceX’s Starship blew itself up in the air, Elon Musk’s private space company has said. Starship underwent its second flight test over the weekend, when the company attempted to send the rocket almost into orbit and then have it land in the ocean. It completed the first part of that mission – but disappeared around eight minutes into its flight. Now the company has confirmed that it lost data from the flight at that moment, which came near the end of the burn of the second stage of the rocket. At that point, the spacecraft used a “safe command destruct” that meant that it caused itself to explode in the air, the company said. It did not say why that had been issued, but did indicate that it had been “appropriately triggered based on available vehicle performance data”. SpaceX noted that until that moment the flight appeared to have been going as planned. The Super Heavy Booster on the bottom of the spacecraft completed a full burn for the first time, for instance, and the two pieces of Starship separated successfully. The booster also managed to flip after it had separated from the upper part of the rocket, SpaceX said. It started another burn then but then “experienced a rapid unscheduled disassembly”, as SpaceX refers to explosions. That came three and a half minutes into the flight and happened around 90 kilometres above the Gulf of Mexico, SpaceX said. The company said that the explosions would prove useful in adjusting future builds of the Starship spacecraft. Before the flight it had explicitly said that the launch was intended as a test and could go wrong – and it reiterated that “while it didn’t happen in a lab or on a test stand, it was absolutely a test”. “With a test like this, success comes from what we learn, and this flight test will help us improve Starship’s reliability as SpaceX seeks to make life multiplanetary,” SpaceX said. “Data review is ongoing as we look for improvements to make for the next flight. The team at Starbase is already working final preparations on the vehicles slated for use in Starship’s third flight test, with Ship and Booster static fires coming up next.” Read More SpaceX launches “limitless” ‘zero fuel’ engine into space SpaceX hints next Starship launch attempt could be soon SpaceX launches world’s most powerful rocket – and then it disappears

Scientists have developed an artificial intelligence (AI) tool that can classify four subtypes of Parkinson’s disease with up to 95% accuracy. Researchers from the Francis Crick Institute and the UCL Queen Square Institute of Neurology in London “trained” a computer program to recognise the subtypes of the condition using images of stem cells from patients. The team said their work, published in the journal Nature Machine Intelligence, could pave the way for personalised medicine and targeted drug discovery. Sonia Gandhi, assistant research director and group leader of the Neurodegeneration Biology Laboratory at the Crick, said: “We understand many of the processes that are causing Parkinson’s in people’s brains. The hope is that one day this could lead to fundamental changes in how we deliver personalised medicine Sonia Gandhi, Francis Crick Institute “But, while they are alive, we have no way of knowing which mechanism is happening, and therefore can’t give precise treatments. “We don’t currently have treatments which make a huge difference in the progression of Parkinson’s disease. “Using a model of the patient’s own neurons, and combining this with large numbers of images, we generated an algorithm to classify certain subtypes – a powerful approach that could open the door to identifying disease subtypes in life. “Taking this one step further, our platform would allow us to first test drugs in stem cell models, and predict whether a patient’s brain cells would be likely to respond to a drug, before enrolling into clinical trials. “The hope is that one day this could lead to fundamental changes in how we deliver personalised medicine.” Parkinson’s is a condition in which parts of the brain become progressively damaged over many years. Symptoms include involuntary shaking of particular parts of the body, slow movement, and stiff and inflexible muscles. But there is also a wide range of other physical and psychological symptoms such as depression and anxiety, problems sleeping, and memory problems. These vary from person to person due to differences in the underlying mechanisms causing the disease. The researchers said that until now, there was no way to accurately differentiate Parkinson’s subtypes. It means people are given nonspecific diagnoses and do not always have access to targeted treatments, support or care, the team added. For the study, the researchers generated stem cells, which have the ability to develop into specialised cell types in the body, from patients’ own cells. The team then used those cells to chemically create four different subtypes of Parkinson’s: two involving pathways leading to toxic build-up of a protein called alpha-synuclein and two involving pathways associated with dysfunctional mitochondria, the cell’s battery packs. Working with the British technology company Faculty AI, the team developed machine-learning algorithms which were able to accurately predict the Parkinson’s subtype when presented with images it had not seen before. James Evans, a PhD student at the Crick and UCL, and first co-author of the study, said: “Now that we use more advanced image techniques, we generate vast quantities of data, much of which is discarded when we manually select a few features of interest. “Using AI in this study enabled us to evaluate a larger number of cell features, and assess the importance of these features in discerning (the) disease subtype. “Using deep learning, we were able to extract much more information from our images than with conventional image analysis. “We now hope to expand this approach to understand how these cellular mechanisms contribute to other subtypes of Parkinson’s.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Oxford scientists find no evidence to suggest Facebook not good for wellbeing Many adults would struggle to understand video-sharing platforms’ rules – Ofcom Ozzy Osbourne PlayStation tweet which failed to reveal link to Sony banned

Cambodian Prime Minister Hun Sen, a devoted and very active user of Facebook — on which he has posted everything from photos of his grandchildren to threats against his political enemies — said Wednesday that he will no longer upload to the platform and will instead depend on the Telegram app to get his message across. Telegram is a popular messaging app that also has a blogging tool called “channels.” In Russia and some of the neighboring countries, it is actively used both by government officials and opposition activists for communicating with mass audiences. Telegram played an important role in coordinating unprecedented anti-government protests in Belarus in 2020, and currently serves as a major source of news about Russia’s war in Ukraine. The 70-year-old year Hun Sen is listed as having 14 million Facebook followers, though critics have suggested a large number are merely “ghost” accounts purchased in bulk from so-called “click farms,” an assertion the long-serving prime minister has repeatedly denied. The Facebook accounts of Joe Biden and Donald Trump by comparison boast 11 million and 34 million followers, respectively, though the United States has about 20 times the population of Cambodia. Hun Sen officially launched his Facebook page on Sept. 20, 2015, after his fierce political rival, opposition leader Sam Rainsy, effectively demonstrated how it could be used to mobilize support. Hun Sen is noted as a canny and sometimes ruthless politician, and has since then managed to drive his rival into exile and neutralize all his challengers, even though Cambodia is a nominally democratic state. Hun Sen said he is giving up Facebook for Telegram because he believes the latter is more effective for communicating. In a Telegram post on Wednesday he said it will be easier for him to get his message out when he is traveling in other countries that officially ban Facebook use. China, the top ally of his government, is also the biggest country with a Facebook ban. Hun Sen has 855,000 followers so far on Telegram, where he appears to have started posting in mid-May. It is also possible that Hun Sen’s social media loyalty switch has to do with controversy over remarks he posted earlier this year on Facebook that in theory could see him get at least temporarily banned from the platform. As the country’s top leader for 38 years, he has earned a reputation for heated rhetoric, and in January, speaking at a road construction ceremony, he decried opposition politicians who accused his ruling Cambodian People’s Paty of stealing votes. “There are only two options. One is to use legal means and the other is to use a stick,” the prime minister said. “Either you face legal action in court, or I rally (the Cambodian) People’s Party people for a demonstration and beat you up.” His remarks were spoken on Facebook Live and kept online as a video. Perhaps because of heightened consciousness about the power of social media to inflame and trigger violence in such countries as India and Myanmar, and because the remarks were made ahead of a general election in Cambodia this July, complaints about his words were lodged with Facebook’s parent company, Meta. Facebook’s moderators declined to recommend action against Hun Sen, judging that his position as a national leader made his remarks newsworthy and therefore not subject to punishment despite their provocative nature. However, the case was forwarded in March to Meta’s Oversight Board, a group of independent experts that is empowered to render an overriding judgment that could limit Hun Sen’s Facebook activities. They may issue a decision in the next few weeks. The case is being closely watched as an indicator of where Facebook will draw the line in countries with volatile political situations. Hun Sen said his Facebook account will remain online but he will no longer actively post to it. He urged people looking for news from him to check YouTube and his Instagram account as well as Telegram, and said he has ordered his office to establish a TikTok account to allow him to communicate with his country’s youth.. ___ Peck reported from Bangkok. Dasha Litvinova contributed from Tallinn, Estonia. Read More Ukraine war’s heaviest fight rages in east - follow live Charity boss speaks out over ‘traumatic’ encounter with royal aide Cambodian lawmakers approve changes to election law that disqualify candidates who don't vote Trump’s latest defence in the classified documents case: ‘Bravado’ Trump gives ‘bravado’ defence for secret papers tape as he sues E Jean Carroll – live

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