Scientists in Israel have created a model of a human embryo from stem cells, without using sperm, eggs or a womb. A team at Israel's Weizmann Institute of Science made the model, which resembles an embryo at day 14, when it acquires internal structures but before it lays down the foundations for body organs, and the work was published in the journal Nature. But the scientists involved said it would take a long time yet to create an embryo from scratch. Team leader Jacob Hanna said the team took stem cells derived from adult human skin cells, as well as others cultured in the lab, then reverted the cells to an early state.They then manipulated them to make a model of an embryo, rather than an actual or synthetic one. "The question is, when does an embryo model become considered an embryo? When that happens, we know the regulations. At the moment we are really, really far off from that point," Hanna said. However, they said the work could open the door to new ways to test the effect of drugs on pregnancies, better understand miscarriages and genetic diseases, and maybe grow transplant tissues and organs. "They are not identical. There are differences from human embryos, but still, this is the first time, if you open an atlas or a textbook, you can say - yeah I can really see the similarity between them," said Hanna. "In about 1 percent of the aggregates we can see that the cells start differentiating correctly, migrating and sorting themselves into the correct structure, and the farthest we could get is day 14 in human embryo development," he said. Their next goal, Hanna said, is to advance to day 21 and also reach a threshold of a 50 per cent success rate. Magdalena Żernicka-Goetz, a professor of development and stem cells at the University of Cambridge, said the study joins six other similar human embryo-like models published from teams around the world this year, including from her lab. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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Going on a spacewalk might sound like a lot of fun – but in reality it’s no walk in the park. From their muscles getting less dense all the way to erectile dysfunction, astronauts have to put up with all sorts of things going wrong with their body. And none more gross than what happens to their fingernails. Turns out they just fall right off. The technical term for this is onycholysis, and it has to do with how much – or how little – atmospheric pressure there is in space. Because there is so little ambient pressure in space, astronaut’s space suits need to be pressurised to keep the human body intact. But that’s not good for the hands, it turns out. “Injuries to the hands are common among astronauts who train for extravehicular activity (EVA),” says a 2015 conference paper by space specialists Wyle Laboratories. “When the gloves are pressurized, they restrict movement and create pressure points during tasks, sometimes resulting in pain, muscle fatigue, abrasions, and occasionally more severe injuries such as onycholysis. “Glove injuries, both anecdotal and recorded, have been reported during EVA training and flight persistently through NASA's history regardless of mission or glove model." A 2010 study looked at 232 hand injuries sustained by astronauts, and found that the wider your knuckle joints, the more likely you are to suffer in a space suit. The study suggested that because space suit gloves limit the mobility of these knuckles, the fingers then get put under more pressure. This, in turn, means less blood gets to the fingers, and risks onycholysis. Ouch. Work has been done to try to improve the design of space suit gloves, of course. One team found that the more tailored they were to each astronaut’s finger length the less likely they were to lose their fingernails. That’s no mean feat, however. These gloves are made of at least four layers: one which touches the skin, one which helps create the pressurised environment, another one which makes the pressure layer less stiff, and an outer layer which protects the astronaut from everything on the outside. Mercifully for NASA astronauts at least, they usually have their gloves fitted to each wearer, and with new space suit design moving forward each day, the number of injuries is decreasing. Nonetheless, it sounds like a trip to space is no time for a manicure. How to join the indy100's free WhatsApp channel Sign up to our free indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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