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A study suggests that convincing yourself that food has a higher calorie content may suppress your appetite and help you lose weight. Alia Crum and her colleagues at Yale University gave 46 healthy volunteers the same 380-calories milkshake. However, some participants were told it was a low-calorie choice, whilst others were told it was high in calories. The 'low-calorie' bottle of the shake claimed it to have zero percent fat, zero added sugar and be only 140 calories. Whilst the 'high-calorie' bottle was labelled as 'indulgent' and accounted to 620 calories. The team measured levels or ghrelin before and after volunteers drank the shake. Ghrelin is a hormone released by the stomach when we are hungry. "It also slows metabolism," Crum said, "just incase you might not find that food." Once you have a big meal after you ghrelin rises, your level proceed to drop again, telling your brain that you've had enough to eat and it's time to start metabolising, in order to burn the calories ingested. Meaning that when we have something like a small salad, ghrelin levels don't drop as much, and metabolism isn't triggered in the same way. For a while, scientists believed that ghrelin levels change in response to the nutrients in your stomach. But Crum's study pushed back on that belief. If participants believed they were drinking the high-calorie shake, the body responded as though the participants had consumed more than they actually had. "The ghrelin levels dropped about three times more when people were consuming the indulgent shake (or though they were consuming the indulgent shake)," Crum said. However, it doesn't mean the nutrients doesn't matter, but Crum suggests that the metabolic model may need to be rethought. "Our beliefs matter in virtually every domain, in everything we do," Crum says. "How much is a mystery, but I don't we've given enough credit to the role of our beliefs in determining our physiology, our reality." Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings. How to join the indy100's free WhatsApp channel

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Divorced men with diabetes are at the highest risk of having some or all of their feet and legs amputated because of it, research has found. According to a study of almost 67,000 people with diabetes in Sweden, people with the condition who are divorced are 67 per cent more likely to have to undergo a lower limb amputation than those who are married. Meanwhile men are at 57 per cent greater risk than women. On average, 184 people a week in England have some part of a lower limb removed surgically to stop infection spreading and killing them. Lasantha Wijesinghe, a consultant vascular surgeon in England who performs lower limb amputations, said they were usually necessary because the person’s life was at risk because of sepsis. The authors of the study, which has not been peer-reviewed yet, said they could not be sure why divorcees of both sexes ran such a greater risk than married people, but speculated that this “may be due to a change in self-care and food habits observed in people when they divorce and are more likely to be living alone”. “Specifically with men, this is often related to more social isolation, with a secondary effect of low physical activity,” they added. Older people are also at higher risk of an amputation and patients who are on insulin treatment, have a pre-existing foot condition such as neuropathy or who smoke are also at higher risk. The study also concluded that obese people have a lower risk than those with a standard weight. The authors could not explain this finding but suggested it could be down to chance. Dr Faye Riley, the research communications manager at Diabetes UK, said: “This study identifies a range of factors that may be linked with a higher risk of amputation among people with diabetes, and raises interesting questions about how social support can influence our health behaviours and outcomes. By pinpointing which people with diabetes are most at risk, support can be targeted where it’s most needed.” Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.