BARCELONA, Spain--(BUSINESS WIRE)--Sep 5, 2023--

A group of major automakers on Wednesday said they were forming a new company to provide electric vehicle

India has ambitious plans for semiconductor manufacturing, but there are challenges along the way.

SANTA ROSA, Calif.--(BUSINESS WIRE)--Jun 15, 2023--

Microsoft has announced a new Xbox showcase, with "more than 20 minutes of trailers and new gameplay footage".

BELMONT, Calif.--(BUSINESS WIRE)--Jun 13, 2023--

Summer is nearly here, and with it arrives June—Pride Month. Although Pride can be a

Workplace messaging app Slack is retiring its status update account on X – formerly Twitter – where it previously shared updates about issues such as outages on the platform. “We made the decision to retire the @SlackStatus account,” the company posted on X. “We’ll continue to share other Slack news and provide support through our main account, @SlackHQ,” it said. The X account had been a useful source of information about ongoing issues with the platform and about problems being investigated by the company. Slack said it is consolidating news related to incidents in its status site. “Moving forward, the Slack Status site, https://status.slack.com, will be the source of truth for all incident news,” the company noted, adding that users can also reach out at feedback@slack.com “with any questions or feedback.” “Alerts will also be available through the RSS and Atom feeds linked at the bottom of the Slack Status home page,” Slack noted. Slack has undergone a number of technical issues this year with the app going offline during the workday for many users globally multiple times. The latest move by Slack to stop providing updates via its status account on X comes as the number of daily active users has declined on the social media platform following Tesla chief Elon Musk’s purchase of the company last year. X chief Linda Yaccarino said earlier this year that the company had about 225 million daily active users at the time – marking a decline of over 10 per cent of users from just before Mr Musk acquired the company. Market intelligence firm Similarweb also noted in a report recently that X’s global traffic is down by about 14 per cent year-on-year in September. Similarweb said the drop in user retention is “a bad sign for app user loyalty” for Twitter following the launch of rival app Threads by Instagram. Mr Musk also noted in July that the platform’s ad revenue was down 50 per cent as social media competition mounts. Other companies, including American Express and Air France have also stopped providing customer service over X. American Express had made its @AskAmex account private, while AirFrance said in April that it would stop offering support to customers via direct messages on the social media platform, The Verge reported. Read More Tesla’s profits dip as Musk goes on rant about staff working from home Elon Musk’s X may charge some users $1 a year to post on platform EU to investigate X’s handling of disinformation over Hamas attack on Israel Could X’s creditors push the social media company into bankruptcy? Slack down: Work chat app goes down as the working day begins Why taking a mental health day could be bad… for your mental health

Olivia Dunne wears a bikini to perform gymnastics on the beach

Amazon is experimenting with using artificial intelligence to sum up customer feedback about products on the site, with the potential to cut down on the time shoppers spend sifting through reviews before making a purchase.

BURLINGTON, Mass.--(BUSINESS WIRE)--Aug 2, 2023--

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.