South Carolina Republicans are one step closer to restricting how race gets taught in K-12 classrooms

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The Street expects the parent of Google and YouTube to post sales of $76 billion, up 10% from a year earlier, with profits of $1.46 a share.

Here is why Pokimane canceled her scheduled stream

By Aditya Kalra and Munsif Vengattil NEW DELHI Streaming giants Netflix, Amazon and Disney on Friday privately discussed

Just days after Sam Altman was fired as OpenAI’s CEO, the board might be considering bringing him back, according to reports. Anonymous sources told both the Wall Street Journal and New York Times that the board is considering walking back on its dramatic firing of Mr Altman. Both outlets reported that Microsoft, a prominent investor in the company, was leading the charge to reinstate Mr Altman. The company announced the leadership change on Friday. “Mr. Altman’s departure follows a deliberative review process by the board, which concluded that he was not consistently candid in his communications with the board, hindering its ability to exercise its responsibilities,” the company wrote. “The board no longer has confidence in his ability to continue leading OpenAI.” While publicly citing communication issues, behind closed doors, the board and Mr Altman appeared to diverge when it came to OpenAI’s future. Mr Altman was hoping to push development more aggressively than the board, CNN reported. Greg Brockman, the president and cofounder of OpenAI who was asked to leave the board, wrote on X that the operation to upend the leadership happened quickly. Mr Altman was asked to join a video call with the board at noon on Friday and was immediately fired. Mr Brockman was not a part of the video meeting, he said. Twenty minutes later, Mr Brockman was told that he could stay in his role, but was being removed from the board, he wrote. “We too are still trying to figure out exactly what happened,” Mr Brockman wrote. He later announced he was quitting “based on today’s news.” Following his exit, Mr Altman wrote on X: “i loved my time at openai. it was transformative for me personally, and hopefully the world a little bit. most of all i loved working with such talented people. will have more to say about what’s next later.” The Times also reported that Mr Altman and Mr Brockman have plans to launch a new startup in the wake of his ouster and are speaking to investors. Those plans have not been made public. Read More OpenAI co-founder Sam Altman ousted as CEO ChatGPT Plus stops signups after major update ChatGPT creator mocks Elon Musk in brutal tweet

Someone slammed Mizzy writing, 'He should stayed locked up for a LONG time. If not for walking in someones home but for stealing someones dog'

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

The mystery client who hired a detective to spy on Reno’s mayor and a county commissioner with GPS trackers has joined an appeal to the Nevada Supreme Court challenging a lower court ruling that his name be made public

Deepfakes are a bit like virus mutations, in that the "best," or even "most effective"