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Jose Hidalgo Named President of FTI as Company Rises to Solve New Challenges in Defense Industry
Jose Hidalgo Named President of FTI as Company Rises to Solve New Challenges in Defense Industry
DAYTON, Ohio--(BUSINESS WIRE)--Sep 7, 2023--
2023-09-07 23:48
Google Meet is testing AI-generated backgrounds
Google Meet is testing AI-generated backgrounds
Getting bored of all the usual Google Meet backgrounds? Soon you'll probably be able to
2023-07-19 22:24
Pokimane drops hint about returning to 'League of Legends', Internet dubs it 'worst decision ever'
Pokimane drops hint about returning to 'League of Legends', Internet dubs it 'worst decision ever'
Pokimane has hinted at returning to 'League of Legends' despite past disagreements and her earlier claim that she will never play the game again
2023-10-03 22:49
UK Heads for Another Sweltering Summer Driven by Global Warming
UK Heads for Another Sweltering Summer Driven by Global Warming
This summer in the UK is expected to be hotter than normal, though temperatures aren’t forecast to break
2023-06-09 01:48
Is xQc in trouble? Adept accuses Kick streamer of impregnating 'two women within one week of each other', trolls say 'wtf is this drama'
Is xQc in trouble? Adept accuses Kick streamer of impregnating 'two women within one week of each other', trolls say 'wtf is this drama'
Prominent streamer xQc is embroiled in controversy as allegations from his ex-girlfriend, Adept, suggest he attempted to impregnate two women
2023-08-15 15:25
Phasmophobia heading to consoles with crossplay support this August
Phasmophobia heading to consoles with crossplay support this August
'Phasmophobia' will be playable on consoles this summer.
2023-06-14 19:23
Gravity Game Arise: “Alterium Shift” at Pax West!
Gravity Game Arise: “Alterium Shift” at Pax West!
TOKYO--(BUSINESS WIRE)--Aug 25, 2023--
2023-08-25 14:16
Scientists may have just found a cure for alcoholism
Scientists may have just found a cure for alcoholism
Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.
2023-08-31 19:46
Don't Skip These Games: 7 Hot Titles You Should Buy This Month
Don't Skip These Games: 7 Hot Titles You Should Buy This Month
For gamers, it’s been a thoroughly stacked year, with blockbuster titles hitting shelves nearly every
2023-07-01 21:58
Google, Microsoft, OpenAI and Anthropic announce industry group to promote safe AI development
Google, Microsoft, OpenAI and Anthropic announce industry group to promote safe AI development
Some of the world's top artificial intelligence companies are launching a new industry body to work together — and with policymakers and researchers — on ways to regulate the development of bleeding-edge AI.
2023-07-26 23:24
See You on the Court: NBA® 2K24 Celebrates the Legendary Kobe Bryant as This Year’s Cover Athlete
See You on the Court: NBA® 2K24 Celebrates the Legendary Kobe Bryant as This Year’s Cover Athlete
NEW YORK--(BUSINESS WIRE)--Jul 7, 2023--
2023-07-07 22:17
Google aims to avoid 'perverse' regulation in Brazil, says executive
Google aims to avoid 'perverse' regulation in Brazil, says executive
By Patricia VilasBoas SAO PAULO The top executive of Google Brazil said on Tuesday the company encourages greater
2023-06-28 07:48